Background: Only data of published study results are available to the scientific community for further use such as informing future research and synthesis of available evidence. If study results are reported selectively, reporting bias and distortion of summarised estimates of effect or harm of treatments can occur. The publication and citation of results of clinical research conducted in Germany was studied.Methods: The protocols of clinical research projects submitted to the research ethics committee of the University of Freiburg in 2000 were (...) analysed. Published full articles in several databases were searched and investigators contacted. Data on study and publication characteristics were extracted from protocols and corresponding publications.Results: 299 study protocols were included. The most frequent study design was randomised controlled trial , followed by uncontrolled studies , laboratory studies and non-randomised studies . 182 were multicentre studies including 97 international collaborations. 152 of 299 had commercial funding and 46 non-commercial funding. 109 of the 225 completed protocols corresponded to at least one full publication ; the publication rate was 48%. 168 of 210 identified publications were cited in articles indexed in the ISI Web of Science. The median was 11 citations per publication .Conclusions: Results of German clinical research projects conducted are largely underreported. Barriers to successful publication need to be identified and appropriate measures taken. Close monitoring of projects until publication and adequate support provided to investigators may help remedy the prevailing underreporting of research. (shrink)

A comparative fMRI study by Peeters et al. (2009) provided evidence that a specific sector of left inferior parietal lobule is devoted to tool use in humans, but not in monkeys. We propose that this area represents the neural substrate of the human capacity to understand tool use by using causal reasoning.

Background: The magnitude of bullying and harassment among psychiatrists is reportedly high, yet no peer-review published studies addressing this issue could be found. Therefore, it was decided to conduct a pilot study to assess the degree of the problem, the types of bullying/harassment and to provide some insights into the situation.Methods and Principal Findings: Following multiple focus group meetings, a yes/no response type questionnaire was developed to assess the degree and type of bullying and harassment experienced by psychiatrists. Over a (...) 3-month period the questionnaire was administered to a random sample of 60 psychiatrists. 57 out of the 60 psychiatrists reported harassment and bullying. Frequencies of the following response variables are presented in descending order: rumours 40% ; defamation 20% ; passing remarks 20% ; false accusations 15% ; threats 13.3% ; verbal abuse 13.3% ; unjustified complaints 13.3% ; promotion blocked 13.3% ; humiliation 13% ; bad reference given 10% ; credentials questioned 8.3% ; physical attacks 5% ; termination 5% ; derogatory remarks 1.7% and 1.7% were subjected to personal work. As a result of being subjected to harassment, 66.7% of the psychiatrists did not take any action, whereas 33.3% confronted the person they believed responsible. Asked whether the bullying and harassment caused distress, 18.3% of the psychiatrists did not report any effect, 30% reported mild distress, 40% moderate distress and severe distress was reported by 11.7%.Conclusions: It was concluded that the magnitude of bullying and harassment among psychiatrists may be quite high, as evidenced by this pilot study. There is a need for extensive systematic studies on this subject and to establish strategies to prevent and address this issue at a national and regulatory level. (shrink)

Different approaches have been proposed in order to achieve knowledge integration for coronary care monitoring applications, usually in the form of expert systems. The clinical impact of these expert systems, which are based only on "shallow" knowledge, has not been remarkable due to the difficulties associated with the construction and maintenance of a complete knowledge base. Model-based systems represent an alternative to these problems because they allow efficient integration of the "deep" knowledge on the underlying physiological phenomena being monitored. In (...) this work, a brief review of existing model-based systems for cardiac rhythm interpretation is presented, followed by the description of a new system forCardiac Arrhythmia Recognition by Model-Based ECG Matching (CARMEM). Fundamental characteristics of CARMEM are presented; in particular, its ability to provide on-line parameter adaptation to simulate complex rhythms and to match observed ECG signals. The proposed model can be useful for the explanation of the origin of cardiac arrhythmias and contribute towards their robust characterization in the context of coronary care units. (shrink)

The phenomenon of probability backflow, previously quantified for a free nonrelativistic particle, is considered for a free particle obeying Dirac's equation. It is shown that probability backflow can occur in the opposite direction to the momentum; that is to say, there exist positive-energy states in which the particle certainly has a positive momentum in a given direction, but for which the component of the probability flux vector in that direction is negative. It is shown that the maximum possible amount of (...) probability that can flow “backwards,” over a given time interval of duration T, depends on the dimensionless parameter ε = (4ℏ/mc2T)1/2, where m is the mass of the particle and c is the speed of light. At ε = 0, the nonrelativistic value of approximately 0.039 for this maximum is recovered. Numerical studies suggest that the maximum decreases monotonically as ε increases from 0, and show that it depends on the size of m, ℏ, and T, unlike the nonrelativistic case. (shrink)

gl. 1. Geopoliticheskai︠a︡ determinat︠s︡ii︠a︡ kulʹtury i ėkonomiki. Rolʹ geograficheskikh faktorov v razvitii obshchestva ; Geopoliticheskie osobennosti sot︠s︡iokulʹturnoĭ istorii Rossii -- gl. 2. Kulʹturnai︠a︡ sostavli︠a︡i︠u︡shchai︠a︡ geopolitiki. Kulʹtura kak instrument geopolitiki ; Dialog kulʹtur v sovremennom mire: opasnai︠a︡ illi︠u︡zii︠a︡, otchai︠a︡nnai︠a︡ vera ili velenie vremeni?

The Need to Understand Factors Influencing Community Participation in Smart City Programs and to Evaluate Their Impact on Urban Progress This study aims to explore the implementation of the Smart City concept in Makassar, focusing on aspects of inclusion, sustainability, and the application of telemedicine technology. The research employs a quantitative methodology, designing a structured questionnaire encompassing variables such as environmental quality, economic vitality, social equity, and technological innovation. Data were collected through various online platforms and analyzed using statistical techniques (...) like correlation analysis and regression modeling. The findings indicate that the majority of participants are males under 30 years old, with backgrounds in farming and entrepreneurship, reflecting high interest in the Smart City concept among this demographic group. These insights are crucial for realizing an inclusive and sustainable Smart City in Makassar and highlight the importance of accessibility and active participation from all community sectors for the success of the Smart City program. (shrink)

George Boole published the pamphlet The Mathematical Analysis of Logic in 1847. He believed that logic should belong to a universal mathematics that would cover both quantitative and nonquantitative research. With his pamphlet, Boole signalled an important change in symbolic logic: in contrast with his predecessors, his thinking was exclusively extensional. Notwithstanding the innovations introduced he accepted all traditional Aristotelean syllogisms. Nevertheless, some criticisms have been raised concerning Boole’s view of Aristotelean logic as the solution of algebraic equations. In order (...) to circumvent such criticisms, we show here how Boole’s conclusions may be deduced from the axioms and inference rules proposed in his pamphlet, from which Aristotle’s deductions in Prior Analytics (including those that are completed through an impossibility) can be stated as theorems. We clarify his method for dealing with both universal and particular premises by means of his symbol v and demystify some criticisms concerning the way he expressed particular premises. Boole’s conclusions for some of those premises for which according to Aristotle there is no deduction are also discussed. The deductive system presented here has the potential to provide a new perspective on Boole’s approach to logic in The Mathematical Analysis of Logic. (shrink)

The logical status of abstraction principles, and especially Hume’s Principle, has been long debated, but the best currently availeble tool for explicating a notion’s logical character—permutation invariance—has not received a lot of attention in this debate. This paper aims to fill this gap. After characterizing abstraction principles as particular mappings from the subsets of a domain into that domain and exploring some of their properties, the paper introduces several distinct notions of permutation invariance for such principles, assessing the philosophical significance (...) of each. (shrink)

You might think that, if you make a law, then that law binds you, because you made it. For, if you will the law, then how can you deny that it binds you, without contradicting your own will? But you might also think the opposite. You might think that, if you are the author of the law, then it cannot bind you. For how can it have authority over you when you have authority over it? How can it bind you (...) when you, the lawmaker, can change it, at will, whenever you like?Now, in that pair of arguments mutually contradictory conclusions are drawn from the selfsame premiss: the premiss that you make the law. So at least one of the arguments is invalid. But, even if they are both invalid, they might still be unignorable, because they might have elements of truth in them. They might be healthy argument–embryos out of which sound arguments could develop. And, whatever else is true, each of the arguments is sufficiently persuasive that, mutually contradictory though they are, each was affirmed in Hobbes’s Leviathan, in much the form in which I just stated them.There are, by my count, four arguments in Hobbes for the conclusion that the citizen is obliged to obey the law. Three of the arguments don’t matter here. (shrink)

Some ways of defending inequality against the charge that it is unjust require premises that egalitarians find easy to dismiss—statements, for example, about the contrasting deserts and/or entitlements of unequally placed people. But a defense of inequality suggested by John Rawls and elaborated by Brian Barry has often proved irresistible even to people of egalitarian outlook. The persuasive power of this defense of inequality has helped to drive authentic egalitarianism, of an old-fashioned, uncompromising kind, out of contemporary political philosophy. The (...) present essay is part of an attempt to bring it back in. (shrink)

1. The present paper is a continuation of my “Self-Ownership, World Ownership, and Equality,” which began with a description of the political philosophy of Robert Nozick. I contended in that essay that the foundational claim of Nozick's philosophy is the thesis of self-ownership, which says that each person is the morally rightful owner of his own person and powers, and, consequently, that each is free to use those powers as he wishes, provided that he does not deploy them aggressively against (...) others. To be sure, he may not harm others, and he may, if necessary, be forced not to harm them, but he should never be forced to help them, as people are in fact forced to help others, according to Nozick, by redistributive taxation. (shrink)

This book presents G. A. Cohen's Gifford Lectures, delivered at the University of Edinburgh in 1996. Focusing on Marxism and Rawlsian liberalism, Cohen draws a connection between these thought systems and the choices that shape a person's life. In the case of Marxism, the relevant life is his own: a communist upbringing in the 1940s in Montreal, which induced a belief in a strongly socialist egalitarian doctrine. The narrative of Cohen's reckoning with that inheritance develops through a series of sophisticated (...) engagements with the central questions of social and political philosophy. In the case of Rawlsian doctrine, Cohen looks to people's lives in general. He argues that egalitarian justice is not only, as Rawlsian liberalism teaches, a matter of rules that define the structure of society, but also a matter of personal attitude and choice. Personal attitude and choice are, moreover, the stuff of which social structure itself is made. Those truths have not informed political philosophy as much as they should, and Cohen's focus on them brings political philosophy closer to moral philosophy, and to the Judeo-Christian ethical tradition, than it has recently been. (shrink)

"A critical study of the interdependence of philosophy as critical theory and man as a free individual."--T.p.

Causal accounts of perception are often believed to lead inevitably to the conclusion that we only indirectly perceive things. The paper argues that there are no incompatibilities between accepting causal accounts of perception (e.G., Many scientific explanations of perception) and holding that we directly perceive physical objects, Without the mediation of sense data. Further, There are strong analogical arguments which support the view that talk of causal accounts of perception is consistent with the philosophical position of direct realism.

In this stimulating work of political philosophy, acclaimed philosopher G. A. Cohen sets out to rescue the egalitarian thesis that in a society in which distributive justice prevails, peopleâes material prospects are roughly equal. Arguing against the Rawlsian version of a just society, Cohen demonstrates that distributive justice does not tolerate deep inequality. In the course of providing a deep and sophisticated critique of Rawlsâes theory of justice, Cohen demonstrates that questions of distributive justice arise not only for the state (...) but also for people in their daily lives. The right rules for the macro scale of public institutions and policies also apply, with suitable adjustments, to the micro level of individual decision-making. Cohen also charges Rawlsâes constructivism with systematically conflating the concept of justice with other concepts. Within the Rawlsian architectonic, justice is not distinguished either from other values or from optimal rules of social regulation. The elimination of those conflations brings justice closer to equality. (shrink)

In this unique work, Professor G.A. Powell Jr. writes: "Thinkers are different from writers—writers are prostitutes. Thinkers desire to be prostitutes." Daily Conversations with My Interloper is first and foremost a celebration of the narrative paradigm, its evolution, latitude of expression, and radical subjectivity in the forms of aphorisms and feuilletons. Following in the literary tradition of Ralph Waldo Emerson, Albert Camus, John Cage, Emile Cioran, and Susan Sontag, et al., the text chronicles Professor Powell's reflections about the ongoing metamorphoses (...) of cultures, influential literary figures, travel, film, history, ennui, quotidian, and the mundane day-to-day existence in which all people participate. Daily Conversations with my Interloper, is a provocative read for the public and private intellectual interested in a panoply of ideas. (shrink)

The article studies the implications for historical materialism of the failure of the socialist project in the Soviet Union. The author demonstrates that the said failure broadly confirms central historical materialist theses, which would have been difficult to sustain if the Russian revolution had succeeded in its goal of superseding capitalism and establishing a socialist society.